2GKU | pdb_00002gku

Structure of the human telomere in k(+) solution: an intramolecular (3 + 1) g-quadruplex scaffold.

(2006) J Am Chem Soc 128: 9963-9970

• PubMed: 16866556 Search on PubMedSearch on PubMed Central
• DOI: https://doi.org/10.1021/ja062791w
• Primary Citation of Related Structures:  
  2GKU


• PubMed Abstract: 
  

  We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.

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Organizational Affiliation: 

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.