Issue 42, 2006
From the journal:

Chemical Communications

Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR

Ziwei Xiao,a   Na Zhang,a   Yiqing Lin,b   Graham B. Jonesb  and  Irving H. Goldberg*a  

* Corresponding authors

a Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
E-mail: irving_goldberg@hms.harvard.edu
Fax: +1 617 4320471
Tel: +1 617 4321787

b Bioorganic and Medicinal Chemistry Laboratories, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA

Abstract

Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.

Graphical abstract: Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR

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Article information

DOI
https://doi.org/10.1039/B610007D
Article type
Communication
Submitted
14 Jul 2006
Accepted
23 Aug 2006
First published
14 Sep 2006

Chem. Commun., 2006, 4431-4433

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Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR

Z. Xiao, N. Zhang, Y. Lin, G. B. Jones and I. H. Goldberg, Chem. Commun., 2006, 4431 DOI: 10.1039/B610007D

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