Issue 20, 2005
From the journal:

Chemical Communications

A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling†

Alexei S. Karpov,a   Eugen Merkul,a   Thomas Oesera  and  Thomas J. J. Müller*a  

* Corresponding authors

a Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, Germany
E-mail: Thomas_J.J.Mueller@urz.uni-heidelberg.de
Fax: +49(0)6221546579
Tel: +49(0)6221546207

Abstract

A novel sequence of Sonogashira coupling and electrophilic addition to an ynone, with concomitant deprotection and cyclocondensation, opens a new one-pot synthesis of 3-halofurans; the method can be readily elaborated to a new sequential Sonogashira–addition–cyclocondensation–Suzuki reaction to furnish 2,3,5-trisubstituted furans in a one-pot fashion.

Graphical abstract: A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling

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Article information

DOI
https://doi.org/10.1039/B502324F
Article type
Communication
Submitted
16 Feb 2005
Accepted
21 Mar 2005
First published
06 Apr 2005

Chem. Commun., 2005, 2581-2583

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A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling

A. S. Karpov, E. Merkul, T. Oeser and T. J. J. Müller, Chem. Commun., 2005, 2581 DOI: 10.1039/B502324F

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