Issue 22, 2005
From the journal:

Chemical Communications

A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis†

Anouk Dirksen,a   Sander Langereis,a   Bas F. M. de Waal,a   Marcel H. P. van Genderen,a   Tilman M. Hackeng*b  and  E. W. Meijer*a  

* Corresponding authors

a Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P. O. Box 513, Eindhoven, The Netherlands
E-mail: E.W.Meijer@tue.nl
Fax: +31 (0)40 2451036
Tel: +31 (0)40 2473101

b Cardiovascular Research Institute Maastricht (CARIM), University Maastricht, P. O. Box 616, Maastricht, The Netherlands
E-mail: T.Hackeng@bioch.unimaas.nl
Fax: +31 (0)43 3884159
Tel: +31 (0)43 3881538

Abstract

The synthesis of a cyclic peptide–Gd(III)DTPA molecule equipped with biotin is presented, yielding a well-defined multivalent MRI contrast agent after its coupling to avidin.

Graphical abstract: A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis

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Article information

DOI
https://doi.org/10.1039/B502347E
Article type
Communication
Submitted
16 Feb 2005
Accepted
01 Apr 2005
First published
14 Apr 2005

Chem. Commun., 2005, 2811-2813

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A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis

A. Dirksen, S. Langereis, B. F. M. de Waal, M. H. P. van Genderen, T. M. Hackeng and E. W. Meijer, Chem. Commun., 2005, 2811 DOI: 10.1039/B502347E

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