From α-helix to β-sheet – a reversible metal ion induced peptide secondary structure switch

Abstract

Here we introduce a peptide model based on an α-helical coiled coil peptide, providing a simple system which can be used for a systematic study of the impact of different metal ions in different oxidation states on peptide secondary structure on a molecular level; histidine residues were incorporated into the heptad repeat to generate possible complexation sites for Cu²⁺ and Zn²⁺ ions.