Issue 11, 2006

Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

Abstract

Amiloride (N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride) has two sets of hydrogen-bond forming sites suitable for target nucleotides and the phosphodiester DNA backbone by which a thymine base opposite an abasic site in DNA duplexes can be recognized with high selectivity and affinity, and it is applicable to the fluorescence detection of thymidine-related SNPs (single-nucleotide polymorphisms) of PCR amplification products.

Graphical abstract: Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

Supplementary files

Article information

Article type
Communication
Submitted
22 Nov 2005
Accepted
12 Jan 2006
First published
30 Jan 2006

Chem. Commun., 2006, 1185-1187

Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: simultaneous binding to DNA phosphate backbone

C. Zhao, Q. Dai, T. Seino, Y. Cui, S. Nishizawa and N. Teramae, Chem. Commun., 2006, 1185 DOI: 10.1039/B516575J

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