Issue 4, 2010
From the journal:

CrystEngComm

Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy†

Sarah Al-Dulaimi,a   Adeyinka Ainaa  and  Jonathan Burley*a  

* Corresponding authors

a Boots Science Building, School of Pharmacy, University of Nottingham, UK
E-mail: jonathan.burley@nottingham.ac.uk
Fax: +44 (0)115 95 15100
Tel: +44 (0)115 84 68357

Abstract

We demonstrate that screening of pharmaceutical compounds for polymorphism can be rapidly achieved for milligram quantities of material using in situ phonon-mode Raman spectroscopy, and suggest that phonon-mode Raman spectra (10–400 cm−1) can be used as “polymorphic fingerprints”.

Graphical abstract: Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy

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Article information

DOI
https://doi.org/10.1039/B921114B
Article type
Communication
Submitted
08 Oct 2009
Accepted
24 Oct 2009
First published
09 Nov 2009

CrystEngComm, 2010,12, 1038-1040

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Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy

S. Al-Dulaimi, A. Aina and J. Burley, CrystEngComm, 2010, 12, 1038 DOI: 10.1039/B921114B

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