One pot transamidation of N-pivaloyl activated amides with anilines in the absence of catalyst, base and additive

Abstract

Transamidation of N-pivaloyl activated amides with weakly-nucleophilic amines such as anilines is demonstrated in the absence of catalyst, base and additives. Under the one-pot conditions, amides were activated in situ by the pivaloyl group and were reacted with anilines at toluene reflux temperature to obtain transamidation products in moderate to excellent yields (60–97%).