Issue 36, 2024
From the journal:

Chemical Communications

A cubic DNA nanocage probe for in situ analysis of miRNA-10b in tumor-derived extracellular vesicles†

Xiaoyan Sun,a   Yafei Chen,a   Haiyan Li,a   Wei Xing,a   Mingli Chen, ORCID logo *ab   Jianhua Wang ORCID logo a  and  Lei Ye ORCID logo *b  

* Corresponding authors

a Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning, P. R. China
E-mail: chenml@mail.neu.edu.cn

b Division of Pure and Applied Biochemistry, Department of Chemistry, Lund University, Box124, 22100 Lund, Sweden
E-mail: lei.ye@tbiokem.lth.se

Abstract

A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.

Graphical abstract: A cubic DNA nanocage probe for in situ analysis of miRNA-10b in tumor-derived extracellular vesicles

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Article information

DOI
https://doi.org/10.1039/D4CC01049C
Article type
Communication
Submitted
05 Mar 2024
Accepted
30 Mar 2024
First published
10 Apr 2024

Chem. Commun., 2024,60, 4777-4780

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A cubic DNA nanocage probe for in situ analysis of miRNA-10b in tumor-derived extracellular vesicles

X. Sun, Y. Chen, H. Li, W. Xing, M. Chen, J. Wang and L. Ye, Chem. Commun., 2024, 60, 4777 DOI: 10.1039/D4CC01049C

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