Biogenic fluorescent carbon dot-decorated mesoporous organosilica nanoparticles for enhanced bioimaging and chemotherapy

Abstract

Hybrid materials possess the unique properties of their individual components, enabling their use in multiple synergistic applications. In this study, we synthesized biogenic fluorescent carbon dots (CDs) decorated with biodegradable periodic mesoporous organosilica nanoparticles (BPMO), creating BPMO@CDs. The CDs, approximately 9.8 nm in diameter, were derived from Musa paradisiaca cv. Awak juice using a rapid microwave method, exhibiting a spherical shape and green and red luminescence. The resulting BPMO@CDs are spherical, around 100 nm in size, and maintain high pore volume and surface area. The elemental chemical state in the BPMO@CDs remains consistent with that of pure BPMO. Our findings demonstrate that BPMO@CDs achieve efficient cellular uptake rates of 46.74% in MCF7 cells and 17.07% in L929 cells, with preserved fluorescence within the cells. The optical properties of the CDs are retained in the BPMO@CDs, allowing for detection upon cellular uptake. Additionally, when loaded with anticancer drugs, the BPMO@CDs significantly enhance the cytotoxicity against MCF7 breast cancer cells, highlighting their potential for synergistic bioimaging and chemotherapy applications.