Issue 18, 2024

BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

Abstract

This report covers boron tribromide (BBr3) mediated dearomative spirocyclization of biaryl ynones. The direct synthesis of spiro[5.5]dienones with a tri-substituted double bond is described for the first time in this paper. The scope of the reaction is broad and the spirocyclic products were obtained in moderate to good yields.

Graphical abstract: BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

Supplementary files

Article information

Article type
Communication
Submitted
20 Feb 2024
Accepted
15 Apr 2024
First published
16 Apr 2024

Org. Biomol. Chem., 2024,22, 3602-3605

BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

G. Jaiswal and S. C. Pan, Org. Biomol. Chem., 2024, 22, 3602 DOI: 10.1039/D4OB00274A

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