Highly selective synthesis of selenium-containing (E)-N-propenolquinazolinones via FeCl3-mediated cascade reaction of propargyl quinazoline-4-yl ethers with diselenides

Abstract

An effective approach for the highly selective synthesis of selenium-containing (E)-N-propenolquinazolinones via an FeCl₃·6H₂O mediated cascade reaction of propargyl quinazoline-4-yl ethers and diselenides has been developed. Mechanistic investigations revealed that the reaction of FeCl₃ and (PhSe)₂ generates, in situ, the electrophilic species PhSe[FeCl₄]·6H₂O, which triggers the cascade reaction.