Issue 10, 2024

Palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates: access to bridged eight-membered oxygen heterocycles

Abstract

In this work, a wide range of bridged eight-membered oxygen heterocycles have been constructed through a novel palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates. The reaction demonstrated a broad substrate scope and afforded the products in good yields with excellent stereoselectivities.

Graphical abstract: Palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates: access to bridged eight-membered oxygen heterocycles

Supplementary files

Article information

Article type
Research Article
Submitted
20 Feb 2024
Accepted
23 Mar 2024
First published
26 Mar 2024

Org. Chem. Front., 2024,11, 2864-2869

Palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates: access to bridged eight-membered oxygen heterocycles

H. Lin, B. Mao, B. Han, J. Luo, Y. Ge, X. Zhang, C. Wang, H. Guo and C. Yuan, Org. Chem. Front., 2024, 11, 2864 DOI: 10.1039/D4QO00329B

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