Microfluidic synthesis of stable and uniform curcumin-loaded solid lipid nanoparticles with high encapsulation efficiency

Abstract

Solid Lipid Nanoparticles (SLNs) are a suitable method for encapsulating poorly soluble curcumin by dispersing the drug in solid lipids. However, the commonly used bulk method has disadvantages such as low reproducibility and encapsulation efficiency. To overcome these issues, we used a microfluidic machine to achieve more uniform mixing, resulting in an encapsulation efficiency of over 60%. The synthesized SLNs released over approximately six days and demonstrated colloidal stability for two weeks without aggregation. To synthesize the SLNs, we equipped the microfluidic machine with a temperature controller, which enabled the large-scale production of more reproducible and stable SLNs compared to those synthesized using the existing microfluidic machines.