A novel strategy of cascade phosphorylation cyclization of 2-isocyanobenzonitrile with phosphine oxide via a DBU-promoted process has been developed. A series of phosphorylated 3-aminoindoles were constructed by forming C–C, C–P and N–P bonds and an amino group in one pot. A plausible reaction mechanism has been proposed based on step-by-step control experiments and 31P NMR analysis.
D. Xu, F. Huang, L. Jin, M. Huang and W. Zhang, Chem. Commun., 2025, 61, 4816 DOI: 10.1039/D5CC00224A
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
