Diastereoselective C(sp3)–H acetoxylation of phosphoramidites

Abstract

Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C–H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.