Two novel analogues of the mannosyl transferase acceptor substrate (GlcNAc)2-Pi-Pi-dolichyl 2 have been prepared in which dolichyl is replaced by phytanyl, 4, and lauryl, 5; both compounds 4 and 5 were synthesized using readily available chitin as the disaccharide precursor. Compound 4 acts as an efficient acceptor substrate for mannosyl transferases from porcine liver and Saccharomyces cerevisiae.
S. L. Flitsch, H. L. Pinches, J. P. Taylor and N. J. Turner, J. Chem. Soc., Perkin Trans. 1, 1992, 2087 DOI: 10.1039/P19920002087
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